Synthesis of Heterocycle-Annelated Naphthyridones with a Bridgehead Nitrogen Atom

Synthesis of a [b]-fused [2,6]naphthyridone

To further demonstrate the versatility of this method, also a representative of a [b]-annelated [2,6]-naphthyridone (compound 19) was prepared, starting from ethyl 3-bromoisonicotinoate (18) [11,12] and (1-methyl-2-benzimidazolyl)acetonitrile [4].

Scheme 4


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nh, 9 May 1996