Department of Clinical
Pharmacy and Diagnostics
University of Vienna
A-1090 Wien, Austria
Clinical Pharmacy is that area within the pharmacy curriculum which investigates by chemical methods the fate of drugs in the body. A clinical pharmacist is therefore a health care provider with a broad chemical knowledge promoting the effective, safe and rational use of drugs by the individual and by the society. Three main topics of Clinical Pharmacy, namely metabolism, pharmacogenetics, and pharmacokinetics, are therefore important research fields in our department. While metabolism and pharmacokinetics strongly influence drug concentration, pharmacokinetics describes the time dependent fate of a drug from absorption until elimination (ADME). Besides known drugs already established on the market, we also investigate the pharmacokinetics and metabolism of various natural and synthetic compounds. As many flavour and fragrance compounds possess pronounced physiological and/or pharmacological activities we do also include these natural plant constituents (mainly terpenes) in our in vitro and in vivo assays. An increasing part in our research activities also deals with the establishment of novel and sensitive diagnostic arrays for future applications in humans. In combination with Clinical Pharmacy, Diagnostics helps to increase efficacy of drug therapy.
Metabolism und transport of drugs in human cancer cell lines transfected with drug metabolizing enzymes and ABC-transporter
Identification of small endogenous molecules as novel biomarkers for the efficacy of cancer therapy by using metabolomic analysis.
Drug monitoring und pharmacokinetics of novel drugs und their metabolites in vivo
Pharmacokinetics, metabolism, and drug monitoring in clinical pharmacy: Impact of blood and tissue levels on efficacy.
Relevancy of the oxidative stress (OS) measurement in disease prevention and treatment monitoring
Pharmacological activity of isolated or synthesized drug metabolites in vitro (cytotoxicity, inhibition of cell growth, antioxidative properties, effects on enzymes and on signal transduction pathways)
ADME of mono- and sequiterpenes as well as phenylpropanoids
Activating and deactivating effects in humans (determination of psychophysiological and neuropsychological parameters)
Modulation of cognitive performance in humans
Effects on sexual arousal and salivary cortisol in humans
Antimicrobial, antiviral and anticancer activities of mono-and sesquiterpenes in vitro
Evaluation of character impact compounds and volatile indicators of adulteration and deterioration of plant fats and fatty oils.
Chemical analysis and olfactory evaluation of essential oils, (semi)volatile compounds and plant extracts and correlation with antimicrobial activity (see above).
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